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. 2019 Mar 1;9:3215. doi: 10.1038/s41598-019-39886-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL233 treatment both before and after doxorubicin administration preserves renal function. (A) Experimental Design; Mice were injected with saline or IL233 for 5 consecutive days either 8 days before (pretreatment) or starting 24hrs, 1 week or 2 weeks after doxorubicin injection. (B) Plasma Creatinine, day 28; (C) Blood Urea Nitrogen, day 28; (D) Real-time PCR analysis of kidney injury markers Kim1 and Ngal, day 28, n ≥ 5. The dotted lines represent the mean of the control group. Symbols represent individual mice; mean ± SEM is shown. * p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; NS p > 0.05 by one-way ANOVA.