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. 2019 Mar 1;9:3215. doi: 10.1038/s41598-019-39886-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Renal injury was significantly lower upon IL233 treatment. (A) Representative hematoxylin and eosin stained sections (A, iii) Saline, (B, i-ii) IL233 Pre-treatment, Scale bars 300 μm (A-i and B-i), 50 μm (A-ii and B-ii); (C) Kidney injury score; (D) Representative images for TUNEL assay to analyze apoptosis, (i) Saline, (ii) pre-treatment, (iii) Enumeration of % apoptotic cells per high-power field. Symbols represent individual mice; mean ± SEM is shown. **p < 0.01; ***p < 0.001; ****p < 0.0001; NS p > 0.05 by one-way ANOVA.