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. 2019 Mar 1;9:3215. doi: 10.1038/s41598-019-39886-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL233 treatment results in higher transporter and progenitor gene expression in kidneys. Real time PCR analysis of (A) renal transporter gene; (B) kidney progenitor genes (also see Supplementary Fig. 2); (C) levels of alarmin cytokine – IL-33. (D) Immunostaining of Saline/IL233-Pre (i) LTL/Sox9/ki67, (ii) Klf4, (iii) LTL/Pax8; Scale: 100 μm. N ≥ 6 except n = 4 for control in panel C, day 28; mean ± SEM is shown. *p < 0.05; NS p > 0.05 by one-way ANOVA.