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. 2019 Mar 1;9:3210. doi: 10.1038/s41598-019-39547-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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5-Fluorouracil and PERK inhibitor synergize to inhibit colon cancer in vivo. (A) (Tumor Volume) and (B) Tumors formed by SW620 cells in NOD/SCID mice treated with solvent control, 20 mg/kg 5-FU, 20 mg/kg PERK inhibitor, or combination of 5-FU and PERK inhibitor for 3 weeks. (C) Tumor weights of (B). (D) Ki67 staining for sectioning of tumors collected from (B). (E) Western blot showing the expression level of ATF4 and cleaved PARP of tumors collected from (B). β-Actin was used as loading control. Data are represented as mean ± SEM or the mean alone.