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. 2019 Mar 1;9:3254. doi: 10.1038/s41598-018-35737-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immune response of mice at different stages. (a) Serum total IgE levels of mice at PND 21 (n = 6/group). μg: microgram, ml: milliliter. (b) Serum total IgE levels of mice at PND56 (n = 12/group). (c) Serum OVA-specific IgE of mice at PND56 (n = 12/group). (d) The percentage of the CD4+ T cells/lymphocytes in spleen are shown (n = 12/group). pg: picogram. The two ends of the horizontal line represent the two compared groups, the asterisk on the line represents significant difference between groups, *p < 0.05, **p < 0.01, ***p < 0.001, for intergroup comparisons. TMC3115, Bifidobacterium bifidum TMC3115; Ceftri, Ceftriaxone; Vanco, Vancomycin. PND, postnatal day.