Table 2.
Mean relative abundance of different taxa at genus level.
| Stage | Genus | Control | Ceftriaxone | Vancomycin | TMC3115 | Ceftri + TMC3115 | Vanco + TMC3115 |
|---|---|---|---|---|---|---|---|
| PND21 | Acinetobacter | <0.01% | 9.45%* | 0.02% | 0.06% | 0.44% | 0.2% |
| Arthrobacter | <0.01% | 1.64%** | <0.01% | <0.01% | 0.08% | <0.01% | |
| Bacteroides | 55.29% | 1.21%** | 0.14%** | 57.78% | 0.12%* | 0.08%** | |
| Bifidobacterium | <0.01% | <0.01% | 0.03% | <0.01% | 12.74%** | 0.42% | |
| Enterococcus | 0.95% | 18.91%* | 0.13% | 0.3% | 78.04%*** | 0.02% | |
| Lactobacillus | 31.8% | 1.22%* | 94.36%*** | 5.86%* | 0.12%* | 96.29%*** | |
| Odoribacter | <0.01% | <0.01% | <0.01% | 2.85%** | <0.01% | <0.01% | |
| Oscillospira | 0.11% | <0.01% | <0.01% | 1.21%* | 0.01% | 0.01% | |
| Parabacteroides | 6.46% | 0.24%** | 0.03%** | 11.32% | <0.01%** | 0.01%** | |
| Prevotella | 0.11% | <0.01% | <0.01% | 1.13%*** | <0.01% | <0.01% | |
| Rummeliibacillus | 0.01% | 16.55%** | <0.01% | <0.01% | 3.14% | <0.01% | |
| Staphylococcus | 0.06% | 35.14%*** | <0.01% | 0.07% | 1.68%** | 0.06% | |
| Stenotrophomonas | 1.28% | 5.91%* | <0.01% | <0.01% | 1.01% | 0.18% | |
| PND56 | AF12 | 1.06% | <0.01%* | 1.21% | 1.25% | <0.01% | <0.01%* |
| Akkermansia | 1.34% | 11.33%* | 0.09% | 1.59% | 5.46%** | 7.78%** | |
| Anaeroplasma | 0.29% | 0.51% | 1.34%* | 0.32% | <0.01% | 0.09% | |
| Bacteroides | 36.3% | 38.41% | 6.97%* | 31.73% | 66.4%* | 61.28%* | |
| Bifidobacterium | <0.01% | <0.01% | <0.01% | 0.01% | <0.01% | <0.01% | |
| Bilophila | 0.56% | 2.26%** | 2.87%** | 2.61%*** | 0.37% | 0.82% | |
| Blautia | 0.49% | <0.01% | <0.01% | 0.26% | 0.65% | 1.55%* | |
| Dehalobacterium | 0.37% | 0.79% | 1.67%** | 1.88%** | 0.01% | <0.01% | |
| Enterococcus | <0.01% | 0.04% | <0.01% | 0.02% | 0.01% | <0.01% | |
| Helicobacter | 2.06% | 0.04%** | 6.36%*** | 1.73% | 1.13% | 0.59%** | |
| Lactobacillus | 12.86% | 0.51% | 23.27% | 9.55% | 3.2% | 0.39% | |
| Mucispirillum | <0.01% | 0.03% | 9.86%** | 0.85% | <0.01% | 0.05% | |
| Odoribacter | 1.95% | <0.01%* | 0.33%* | 2.05% | <0.01%* | <0.01%* | |
| Oscillospira | 4.91% | 18.98% | 23.91%** | 21.67%* | 1.36% | 1.7% | |
| Parabacteroides | 11.97% | 14.71% | 0.94%* | 3.09% | 13.2% | 22.65%* | |
| Prevotella | 5.38% | 0.01%* | 0.54% | 1.8% | <0.01%* | <0.01%* | |
| Ruminococcus | 1.33% | 1.55% | 7.93%** | 6.14% | <0.01% | 0.13% | |
| Sutterella | 1.4% | <0.01%*** | 0.71% | 0.05%** | 1.6% | <0.01%** | |
| Trabulsiella | <0.01% | <0.01% | 0.9% | <0.01% | 1.02%*** | 1.8%*** |
n = 4/group; *p < 0.05, **p < 0.01, ***p < 0.001, comparing with control. TMC3115, Bifidobacterium bifidum TMC3115; Ceftri, Ceftriaxone; Vanco, Vancomycin; PND, postnatal day.