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. 2019 Mar 1;9:3301. doi: 10.1038/s41598-019-38934-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Patient age and VA at baseline. (A) Patient age at first treatment slightly increased over the years. Patients from 2012 onwards were statistically significantly older compared to 2009 (*p < 0.05, Dunnet’s t-test). (B) Baseline VA did not differ over the years. Horizontal lines show VA inclusion limits for MARINA and ANCHOR clinical trials. Note that only 60.6% of our real life cohort falls into the VA inclusion criteria of these clinical trials. Baseline VA for this analysis was adjusted for differences between decimal and ETDRS measurements based on Falkenstein et al.⁴.