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. 2019 Mar 1;9:3235. doi: 10.1038/s41598-019-39594-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DNA repair gene variants are associated with increased mutation and neoantigen count. (a) Presence of somatic variants in homologous recombination (HR), mismatch repair (MMR) or polymerase epsilon (POLE) were associated with increased mutation burden. (b) Mutation count increases with higher number of DNA repair gene variants. (c) Neoantigen burden similarly was associated with DNA repair gene variants and (d) with the number of affected genes. Statistical analysis completed with Student’s t-test (a,c) and one-way ANOVA with Tukey’s test for multiple comparisons (b,d), *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.