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. 2019 Mar 1;9:3235. doi: 10.1038/s41598-019-39594-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activated T cell infiltration is increased in high-mutation tumors and associated with a specific immunophenotype. (a) Tumors with higher mutation burden were more likely to contain activated (Act) CD4+ and CD8+ activated T cells, though this difference was not significant after adjusting for multiple comparisons. (b) Activated CD4+ and CD8+ T cells were both positively correlated with CD4+ effector memory T cells (Tem), type 2 helper cells (Th2), memory (Mem) B cells, myeloid dendritic cells (mDC), and myeloid-derived suppressor cells (MDSC). Additional cell types analyzed include central memory T cells (Tcm); follicular helper T cells (Tfh); regulatory T cells (Tregs); gamma-delta T cells (Tgd); dendritic cells (DC); immature dendritic cells (iDC); plasmacytoid dendritic cells (pDC); macrophages (Mac); neutrophils (Neu); monocytes (Mono); eosinophils (Eos); mast cells (Mast); natural killer cells (NK); CD56 bright NK cells (NK Bright); CD56 dim NK cells (NK Dim); and natural killer T cells (NKT).