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. 2019 Mar 1;9:3235. doi: 10.1038/s41598-019-39594-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DNA repair gene variants and immune signals together predict infiltration by activated T cells. (a) DNA repair gene variants did not lead to a change in activated T cell infiltration. (b) These findings suggested that the tumors could be divided into four immunophenotypic groups based on DNA repair status and T cell infiltration. (c) A heat map of immunosuppressive genes showed differential mRNA expression among these groups. (d) A combined score incorporating DNA repair gene variants as well as TGFB1 and WNT2 expression was significantly associated with activated T cell infiltration (proportion Z-score, *FDR-adjusted p-value < 0.05, ***p < 0.001).