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. 2019 Mar 1;9:3235. doi: 10.1038/s41598-019-39594-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mutation burden is associated with a unique immune and clinical profile. (a) High mutation burden was associated with an immune signature that includes increased expression of genes related to cytolytic and interferon-γ signaling. (b) A volcano plot shows differential mRNA expression in low versus high mutation tumors (Student’s t-test with FDR-adjusted p-values). Unique immune signatures were associated with (c) neoantigen load and (d) immunophenotypic group. (e) Mutation burden was not associated with significant differences in overall and disease-free survival. (f) High neoantigen burden was not associated with overall survival, but did lead to worse disease-free survival (g) Presence of DNA repair gene variants did not affect overall or disease-free survival. Kaplan-Meier plots shown, **p < 0.01 based on log-rank test.