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. 2019 Mar 1;10:989. doi: 10.1038/s41467-019-08953-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — MicroPET/CT imaging with ¹⁸F-DBPOF-c(RGDyk) and ¹⁸F-DBPOF-HSA. a A PET image from a dynamic scan with ¹⁸F-DBPOF-c(RGDyk) in U87MG nude mice bearing gliomablastoma, reconstructed at 23 min post-injection with the tumor (T), live (L), and kidney (K) indicated by white arrows. The inset image in the right corner showed no specific tumor uptake indicated by a white arrow. b Time-activity curves of ¹⁸F-DBPOF-c(RGDyk) in the tumor, bone, blood, kidney and muscle. Uptake values are presented by means ± standard deviations (n = 3). c A PET image from a 60 min dynamic scan with ¹⁸F-DBPOF-HAS in healthy female Wistar rats, reconstructed at 60 min post-injection with the heart (H) and artery (A) indicated by white arrows. d Time-activity curves of ¹⁸F-DBPOF-HSA in the heart, liver, bone and muscle. Uptake values are presented by means ± standard deviations (n = 3). Source data are provided as a Source Data file