Table 1.

Comparison of flourophosphines with various degrees of steric hindrance

Results of RCY are presented by means  ±  standard deviations (n  =  3)

^aP-F bond energy calculated by Gaussian 09

^bAll RCYs are experimental values acquired under the same conditions, where 1.0 μmol of precursor was dissolved in 100 μL of DMSO, 100 μL of [¹⁸F]F^- aqueous solution from the cyclotron target was added, and the reaction was carried out at 75 °C for 15  min. All yields are presented at EOS without decay correction, and each experiment was repeated for 3 times

^cFraction of the intact ¹⁸F-labeled fluorophosphine synthons in the plasma of male BALB/c nude mice at 120  min after tail vein injection