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. 2019 Mar 1;9:3312. doi: 10.1038/s41598-019-39842-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cy3-labeled crotamine is reabsorbed from pro-urine by PTECs. Kidney sections from mice receiving vehicle (a–d) or a single ip administration of fluorescently-labeled Cy3-crotamine (5 µg/animal), 2 h before animal euthanasia (e–j). Fluorescence microscopy of transversal section of whole kidney (a and e), in which the boxes correspond to the areas magnified (as presented in b,c,d,f,g and h). Zoom out of kidney transversal section of mice showing the presence of Cy3-crotamine in the brush borders area of PTECs (i,j). Differential interference contrast (DIC) showing kidney tissue structure with nuclei stained with DAPI (blue) (b,f), and Cy3-crotamine stained in red (a,c,d,e,g,h and j). Differential interference contrast (DIC) image (i), and overlay of red and blue fluorescence with DIC (d,h and j). Bar = 1 mm (a,e), 50 μm (b–d, f–h), and 20 μm (i, j).