Table 1.

Main organs and body weight, femur size, food and water intake and renal function parameters.

		Control	Crotamine
Kidney (g)		0.34 ± 0.01	0.33 ± 0.01
Liver (g)		1.14 ± 0.07	1.11 ± 0.09
Heart (g)		0.14 ± 0.01	0.13 ± 0.01
Femur (cm)		1.58 ± 0.01	1.56 ± 0.02
Body Weight (g)		25.78 ± 0.71	24.88 ± 0.72
Food Intake (g/24 h/5 mice)		83.50 ± 2.08	76.32 ± 1.95*
Water Intake (mL/24 h/5 mice)		21.62 ± 0.72	18.39 ± 0.93*
Creatinine (mg/dL)	Plasma	2.84 ± 0.61	2.39 ± 0.42
	Urine	3.86 ± 0.07	2.91 ± 0.48
Uric acid (mg/dL)	Plasma	1.55 ± 1.01	1.89 ± 0.64
	Urine	2.30 ± 0.53	3.73 ± 0.40

Measurements of body and organs weights, femur size and plasma and urine biochemical biomarkers analyses were performed at the end of the treatment for 21 days with crotamine (1 μg/animal/day). For food and water intake assessment measures were performed at every 4 days, and the presented data correspond to the final mean value of consumption after the end of 21 days treatment period.

*p < 0.05 for t-Student statistical test. Results are expressed as mean ± SEM (N = 5 per group).