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. 2019 Mar 1;9:3279. doi: 10.1038/s41598-019-39890-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In-vitro and in-vivo neutralizing activity of purified human polyclonal antibodies. (A) Increased toxin neutralizing activity of purified human polyclonal antibodies compared to IVIG. (B–D) Active protection: mice were challenged with toxins either pre-incubated with purified human polyclonal Abs (open symbols) or IVIG (grey symbols) or with toxin only (black symbols). (E) Passive protection: mice were treated with anti-SEB pAbs 6 h post SEB challenge.