Table 2.
Multivariate analysis of the association between clinicopathological characteristics and ancestry background and EGFR and KRAS mutations.
| Variables | Parameters | Total (n) | OR | 95% CI | p-value | |
|---|---|---|---|---|---|---|
| EGFR | Gender | Male | 224 | 1 | Ref. | Ref. |
| Female | 196 | 1.67 | 0.98–2.85 | 0.058 | ||
| Tobacco | Never | 126 | 5.11 | 2.71–9.62 | <0.0001 | |
| Current smoker | 166 | 0.59 | 0.28–1.24 | 0.16 | ||
| Former smoker | 128 | 1 | Ref. | Ref. | ||
| ASN Ancestry | Low | 140 | 1 | Ref. | Ref. | |
| Intermediate | 138 | 1.05 | 0.54–2.04 | 0.88 | ||
| High | 142 | 2.01 | 1.09–3.71 | 0.03 | ||
| PS ECOG | 0 | 44 | 3.94 | 1.47–10.57 | 0.006 | |
| 1 | 222 | 1.67 | 0.79–3.53 | 0.18 | ||
| 2 | 67 | 1.2 | 0.46–3.13 | 0.72 | ||
| 3 or 4 | 84 | 1 | Ref. | Ref | ||
| KRAS | Tobacco | Never | 126 | 1 | Ref. | Ref. |
| Current smoker | 166 | 3.42 | 1.67–7.00 | 0.001 | ||
| Former smoker | 128 | 3.74 | 1.79–7.81 | <0.0001 | ||
| ASN Ancestry | Low | 140 | 1.93 | 1.06–3.52 | 0.03 | |
| Intermediate | 138 | 1.31 | 0.69–2.46 | 0.41 | ||
| High | 142 | 1 | Ref. | Ref. |
n, number of patients; OR, odds ratio; 95% CI, 95% confidence interval; p-value: significance of Wald test.; ASN, Asian race; Ref., reference group; PS ECOG, performance status ECOG (Eastern Cooperative Oncology Group). Significant associations are indicated in bold.