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. 2019 Mar 1;9:3266. doi: 10.1038/s41598-019-39796-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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VarClass Score for Selecting Pro-disease and Protective Variants. VarClass output showing True versus Mock (imputed) variants distribution using IDI score for the validation cohorts GSE8055 (n = 928) and GSE8054 (n = 1189), known to be associated with Pancreatic Cancer. T-test results: t = 13.345 for df = 3212.6, and a p-value: < 2.2e-16. The brown gradient arrow and dashed lines show the selected cut-offs of 0.02 and −0.02 for pro-disease and protective variants respectively.