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. 2019 Mar 1;9:3328. doi: 10.1038/s41598-019-39298-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Validation of expression and relationship of the key genes. (A) HPCs and HMCs were cultured in vitro and stimulated by high glucose. Expression of the key lncRNAs and some of their co-expressed mRNAs were tested by qPCR. Relative expression in high glucose group was normalized to expression in normally cultured cells. LncRNA NR_130134.1 (B) and NR_029395.1 (C) were knocked down by specific siRNA in cultured HMCs. After that, high glucose (40 mM) was added for 24 h. Expression of related mRNAs was tested in each group. n = 3, *P < 0.05 vs. Control group. ^#P < 0.05 vs. high glucose group. (D) Expression of three key lncRNAs was tested by FISH in high glucose-stimulated HMCs.