Fig. 5.

Activating a dormant redundancy between paralogs is one mechanism of essentiality bypass. a Schematic illustrating how an essential gene (‘E’ in blue) can be rendered dispensable by the overexpression (OE) of its paralog (“P” in green), and tetrad dissection showing that the essentiality of five query essential genes can be bypassed by overexpressing their respective paralogs. b Two hypothetical scenarios of paralog-dependent bypass achieved by altering a non-paralogous suppressor gene (“S” in orange) and two examples of paralog-dependent bypass