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. 2019 Mar 1;10:1002. doi: 10.1038/s41467-019-08928-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — BOE interactions are strongly correlated with functional relatedness. a Schematic depicting the two types of gene pairs for which the enrichment of functionally related genes within pairs were analyzed. b–d The numbers of observed interacting gene pairs in which b both genes are associated with the same biological process GO slim term, c the protein products of both genes are located in the same subcellular location, or d the protein products of the two genes physically interact, were compared with the expected numbers from all possible pairs generated by permutation. e–g The numbers of observed interactor-sharing gene pairs in which e both genes are associated with the same biological process GO slim term, f the protein products of both genes are located in the same subcellular location, or g the protein products of the two genes physically interact, were compared with the expected numbers from all possible pairs