Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 1;10:1002. doi: 10.1038/s41467-019-08928-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — Examples demonstrating the power of BOE analysis to infer gene functions. a Schematic showing the relationships between rad21, its paralog rec8, and the Mmi1 pathway. b Mmi1 fused with a homodimeric leucine zipper (Mmi1-LZ) rescued the gene repression defect of erh1Δ. DSR-fused lacZ gene (lacZ-DSR) was used as a reporter. lacZ expressed in WT was used as a normalization control. c A scatter plot showing log2-transformed fold changes (Log2FC) of mRNA abundance relative to WT in erh1Δ and erh1Δ expressing Mmi1-LZ. mRNAs upregulated in erh1Δ are highlighted in red. d A model of how Erh1 functions. e jmj3 can be bypassed by the K4R mutation in histone H3. f jmj3 can be bypassed by the PHD domain truncation of png1. g A model depicting the Set1C-H3K4me-Png1 axis that causes the lethality of lid2Δ and jmj3Δ. h A model explaining how rrp2Δ can suppress slx8-ts (left) and a model explaining how rrp2Δ can suppress slx8Δ (right). i BOE analysis identified 16 genes (gray nodes), when individually deleted, can suppress the lethality of at least one of five synthetic-lethal double deletion mutants (green nodes). j A diagram depicting the fission yeast Shu complex, including the two subunits newly identified in this study