Table 1.

Studies identified as a result of a systematic review of vaccines tested over multiple pathogen challenge doses. Inclusion criteria included studies where vaccinees (vaccinated individuals) and an unvaccinated control group were tested against multiple pathogen doses in the same study. *Indicates a study in which only two pathogen doses were tested for a seronegative participant group, but three doses were tested across vaccinees.

Study	No. of Challenge Doses	Study Organism	Pathogen	Response Variable	Citation
Bosseray 1980	5	Mouse	Brucella abortus	Placental colonization	25
Bublot 2007	6	Chicken	H5N1 Influenza	Mortality	32
Chernokhaeva 2016	3	Mouse	Tick-borne encephalitis virus	Infection and Mortality	31
Churcher 2017	4	Mouse	Malaria	Infection	28
Cronly-Dillon 1972	2	Mouse	Salmonella sv. typhimurium	Infection	7
Delagrave 2012	4	Mouse	Herpes simplex virus Type 2	Mortality	33
Ghiasi 1997	2	Mouse	Herpes simplex virus Type 1	Mortality	34
Henry 1966	5	Human	Poliovirus	Infection	29
Hatch 1964	12	Mouse	Francisella (Pasteurella) tularensis	Mortality	35
Islam 2007	2	Chicken	Mareks Disease virus	Infection	5
Marchart 2003	3	Mouse	Pasteurella multocida	Mortality	8
Miller 2006	2	Duck	Duck hepatitus B virus	Chronic infection	26
Plotkin 1989	2*	Human	Human cytomegalovirus	Infection	27
Sebunya 1982	3	Mouse	Haemophilus pleuropneumoniae	Mortality	36
van Loon 2002	3	Chicken	Reovirus	Isolation from organ	30
Yamashita 2009	2	Sevenband grouper	Red-spotted grouper nervous necrosis virus	Mortality	37