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. 2019 Mar 1;5:7. doi: 10.1038/s41540-019-0087-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Metabolizer graphic interface with a representation of the modules. On the right side there is a list of KEGG pathways with arrows up or down in case they contain modules with up or down activations, respectively. When the arrow is gray, the change in activity is not significant. Red up arrows indicates a significant increase in activity and blue down arrow a significant decrease of activity in the module. Below the pathway list, there is another list with the modules within the pathway with the same code for arrows