Table 6.
KEGG modules with activity significantly associated to patient survival in both KIRC and LIHC tumors. BRCA and PRAD did not show any significant result
| KIRC | LIHC | BRCA | PRAD | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| KEGG module ID | Final metabolite | Module name | Metabolic categories | FDR adj. p-value | X2 statistic | FDR adj. p-value | X2 statistic | FDR adj. p-value | X2 statistic | FDR adj. p-value | X2 statistic |
| M00004 | Pentose phosphate cycle | Pentose phosphate pathway (Pentose phosphate cycle) | Carbohydrate | 0.04415 | 5.51536 | 0.01654 | 8.56769 | 0.95894 | 0.08936 | 1.00000 | 0.34950 |
| M00020 | l-Serine | Serine biosynthesis. glycerate-3P ⇒ serine | Amino acid | 0.04343 | 5.59083 | 0.01902 | 8.00418 | 0.68795 | 2.02105 | 1.00000 | 0.04439 |
| M00029_1 | Fumarate | Urea cycle | Amino acid | 0.03695 | 5.97270 | 0.02789 | 7.10368 | 0.95894 | 0.12874 | 1.00000 | 1.58333 |
| M00029_2 | Urea | Urea cycle | Amino acid | 0.01324 | 8.08771 | 0.04608 | 5.78630 | 0.97489 | 0.01307 | 1.00000 | 1.50000 |
| M00032 | Acetoacetyl-CoA | Lysine degradation. lysine ⇒ saccharopine ⇒ acetoacetyl-CoA | Amino acid | 0.00002 | 22.4506 | 0.01902 | 7.86930 | 0.97489 | 0.06041 | 1.00000 | 0.09094 |
| M00036 | Acetoacetate | Leucine degradation. Leucine ⇒ acetoacetate acetyl-CoA | Amino acid | <10−6 | 27.1764 | 0.00593 | 11.7331 | 0.97489 | 0.01729 | 1.00000 | 0.01493 |
| M00050 | GTP | Guanine ribonucleotide biosynthesis. IMP ⇒ GDP.GTP | Nucleotide | 0.00002 | 22.0824 | 0.00222 | 14.8778 | 0.97489 | 0.01269 | 1.00000 | 0.03406 |
| M00051_1 | UMP | Uridine monophosphate biosynthesis. glutamine (PRPP) ⇒ UMP | Nucleotide | 0.01324 | 8.08552 | 0.00295 | 13.7996 | 0.77769 | 1.21228 | 1.00000 | 0.31132 |
| M00052 | CDP | Pyrimidine ribonucleotide biosynthesis. UMP ⇒ UDP/UTP.CDP/CTP | Nucleotide | <10−6 | 36.4353 | 0.01796 | 8.31921 | 0.95894 | 0.45008 | 1.00000 | 0.33263 |
| M00071 | Neolactotetraosylceramide | Glycosphingolipid biosynthesis. neolacto-series. LacCer ⇒ nLc4Cer | Carbohydrate | 0.00056 | 14.6064 | 0.01902 | 7.88317 | 0.95894 | 0.26129 | 1.00000 | 0.00638 |
| M00085_1 | Acyl-CoA | Fatty acid biosynthesis. Elongation. mitochondria | Lipid | 0.00056 | 14.6836 | 0.04608 | 5.75749 | 0.98608 | 0.00096 | 1.00000 | 0.62210 |
| M00087 | Tetradecanoyl-CoA | beta-Oxidation | Lipid | <10−6 | 37.0408 | 0.03214 | 6.63945 | 0.68795 | 1.76506 | 1.00000 | 0.02158 |
| M00131 | myo-Inositol | Inositol phosphate metabolism. Ins(1.3.4.5)P4 ⇒ Ins(1.3.4)P3 ⇒ myo-inositol | Lipid | <10−6 | 27.9721 | 0.00222 | 16.1345 | 0.97489 | 0.04363 | 1.00000 | 0.13613 |
| M00741 | Succinyl-CoA | Propanoyl-CoA metabolism. propanoyl-CoA ⇒ succinyl-CoA | Carbohydrate | <10−6 | 38.7000 | 0.00826 | 10.3022 | 0.52040 | 3.42237 | 1.00000 | 1.08333 |