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. 2019 Mar 1;9:3289. doi: 10.1038/s41598-019-39772-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Total numbers of circulating stem cell subpopulations per mL of peripheral blood. (A) CD34+CD38– HSCs. (B) CD34+CD38+ HPCs. (C) Lin-CD34+CD45− VSELs. (D) Lin-CD133+CD45− VSELs. (E) Lin-CD34+CD45+ HSCs. (F) Lin-CD133+CD45+ HSCs. Comparisons between the control and septic groups were performed by Mann-Whitney U test. Statistical significance between values for healthy controls and septic shock patients are marked as follows: *p < 0.05 and **p < 0.01. The comparison of the cell number between days 1 and 3 by the Wilcoxon signed-rank test did not reveal significant differences.