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. 2019 Mar 1;9:3320. doi: 10.1038/s41598-019-39933-5

Table 4.

Hazard ratios (with 95% CIs) for variables evaluated as potential predictors of all-cause mortality in the GA cohort.

Variables n (%) HR 95% CI P value
Male 514 (70.9) 1.00 Reference Reference
Female 211 (29.1) 1.13 0.71–1.78 0.608
Age
1 year increase 725 (100) 1.05 1.02–1.07 <0.0001
Duration of PD (year)
<2 310 (42.8) 1.00 Reference Reference
2 ≤ < 4 204 (28.1) 1.80 1.06–3.06 0.029
4 ≤ < 6 116 (16.0) 2.03 1.02–4.03 0.043
6 ≤ < 8 57 (7.9) 3.17 1.36–7.37 0.007
8≤ 38 (5.2) 2.27 0.88–5.85 0.087
Type of diabetes
Type 2 637 (87.9) 1.00 Reference Reference
Type 1 88 (12.1) 1.09 0.57–2.11 0.782
CVD comorbidity
No 535 (73.8) 1.00 Reference Reference
Yes 190 (26.2) 2.69 1.71–4.24 <0.0001
Smoking
No 566 (89.0) 1.00 Reference Reference
Yes 70 (11.0) 1.22 0.58–2.59 0.592
Antihypertensive agent
User 551 (83.6) 1.00 Reference Reference
Non-user 108 (16.4) 1.93 1.12–3.33 0.017
HD combination
No 553 (76.3) 1.00 Reference Reference
Yes 172 (23.7) 1.01 0.58–1.76 0.971
Residual renal function
Non-anuric 429 (79.2) 1.00 Reference Reference
Anuric 113 (20.8) 1.78 1.01–3.22 0.041
Type of dialysate
2.5% non-user 367 (56.4) 1.00 Reference Reference
2.5% user 284 (43.6) 2.19 1.34–3.59 0.002
Type of dialysate
Icodextrin non-user 302 (46.4) 1.00 Reference Reference
Icodextrin user 349 (53.6) 1.15 0.73–1.83 0.528
Type of treatment
APD non-user 346 (53.7) 1.00 Reference Reference
APD user 298 (46.3) 0.74 0.48–1.19 0.236
Total Kt/V
<1.1 55 (11.9) 3.43 1.33–8.83 0.011
1.1 ≤ < 1.4 64 (13.8) 2.53 0.93–6.93 0.068
1.4 ≤ < 1.7 102 (22.0) 1.00 Reference Reference
1.7 ≤ < 2.0 107 (23.1) 0.74 0.27–2.05 0.573
2.0≤ 135 (29.2) 1.02 0.41–2.51 0.972
Body mass index (kg/m2)
<20.0 62 (9.9) 2.68 1.25–5.77 0.011
20 ≤ < 22 102 (16.4) 1.15 0.53–2.94 0.708
22 ≤ < 24 153 (24.5) 1.00 Reference Reference
24 ≤ < 26 123 (19.7) 0.76 0.35–1.64 0.488
26 ≤ < 28 84 (13.5) 0.94 0.41–2.19 0.895
28≤ 100 (16.0) 0.67 0.28–1.58 0.364
Serum albumin (g/dL)
<2.5 47 (6.6) 12.0 5.17–27.9 <0.0001
2.5 ≤ < 3.0 141 (19.9) 1.35 0.70–2.57 0.365
3.0 ≤ < 3.5 283 (40.0) 1.00 Reference Reference
3.5 ≤ < 4.0 193 (27.3) 0.59 0.30–1.16 0.129
4.0≤ 44 (6.2) 0.17 0.02–1.25 0.082
Hemoglobin
1 g/dL increase 711 (98.1) 0.71 0.59–0.84 <0.0001
C-reactive protein
1 mg/dL increase 646 (89.1) 1.39 1.18–1.64 <0.0001
Total cholesterol (mg/dL)
<130 83 (13.5) 1.26 0.58–2.74 0.552
130 ≤ < 150 105 (17.2) 0.78 0.37–1.64 0.524
150 ≤ < 170 124 (20.3) 1.00 Reference Reference
170 ≤ < 190 108 (17.7) 0.75 0.36–1.53 0.432
190 ≤ < 210 89 (14.5) 0.76 0.36–1.63 0.492
210≤ 103 (16.8) 0.23 0.08–0.60 0.003
HDL-cholesterol (mg/dL)
<30 70 (11.8) 3.18 1.49–6.79 0.003
30 ≤ < 40 176 (29.7) 0.84 0.41–1.69 0.633
40 ≤ < 50 148 (25.0) 1.00 Reference Reference
50 ≤ < 60 89 (15.0) 1.12 0.49–2.51 0.791
60 ≤ < 70 59 (10.0) 0.44 0.14–1.39 0.165
70≤ 50 (8.5) 0.41 0.11–1.50 0.179
Calcium (mg/dL)
<8.0 154 (21.7) 0.72 0.29–1.75 0.473
8.0 ≤ < 8.5 159 (22.4) 0.96 0.45–2.03 0.918
8.5 ≤ < 9.0 185 (26.1) 1.00 Reference Reference
9.0 ≤ < 9.5 116 (16.4) 0.76 0.34–1.68 0.508
9.5 ≤ < 10.0 66 (9.3) 0.78 0.29–2.09 0.629
10≤ 29 (4.1) 1.83 0.64–5.18 0.253
Phosphate (mg/dL)
<4.0 107 (14.8) 1.47 0.75–2.88 0.258
4.0 ≤ < 5.0 210 (27.8) 1.47 0.83–2.60 0.179
5.0 ≤ < 6.0 221 (30.5) 1.00 Reference Reference
6.0 ≤ < 7.0 115 (15.9) 1.04 0.51–2.13 0.903
7.0 ≤ < 8.0 58 (8.0) 1.52 0.64–3.58 0.335
8.0≤ 22 (3.0) 0.42 0.05–3.39 0.418
Intact-PTH (pg/mL)
<60 119 (18.3) 1.42 0.61–3.34 0.412
60 ≤ < 140 181 (27.9) 1.23 0.53–2.84 0.617
140 ≤ < 220 151 (23.2) 1.00 Reference Reference
220 ≤ < 300 88 (13.5) 1.17 0.48–2.85 0.718
300 ≤ < 380 44 (6.8) 0.63 0.18–2.12 0.461
380≤ 67 (10.3) 1.71 0.52–5.57 0.368

CVD, cardiovascular disease; HD, hemodialysis; HDL, high-density lipoprotein; PD, peritoneal dialysis; PTH, parathyroid hormone.