Table 2.
Action potential durations of left and right atrial myocytes by genotype before and after DTX-K (10 nM)
| Left Atrium (WT n = 4/3; KO n = 4/3) |
Right Atrium (WT n = 4/4; KO n = 3/3) |
|||
|---|---|---|---|---|
| Control | DTX-K | Control | DTX-K | |
| WT | ||||
| APD30, ms | 6.1 ± 1.6 | 5.4 ± 0.7 | 5.4 ± 1.3 | 5.7 ± 1.5 |
| APD50, ms | 8.8 ± 2.0 | 8.2 ± 1.2 | 7.5 ± 1.4 | 8.3 ± 1.7 |
| APD90, ms | 50.8 ± 4.9 | 73.7 ± 6.4* | 43.5 ± 4.1 | 65.7 ± 5.0* |
| Kcna1−/− | ||||
| APD30, ms | 7.3 ± 0.8 | 7.0 ± 0.8 | 6.8 ± 0.5 | 7.0 ± 0.2 |
| APD50, ms | 13.0 ± 1.9 | 13.3 ± 2.0 | 9.4 ± 0.7 | 9.6 ± 0.2 |
| APD90, ms | 72.1 ± 3.9 | 71.6 ± 8.7 | 107.7 ± 14.0 | 92.1 ± 1.4 |
Values are means ± SE. APD30, APD50, and APD90, action potential duration at 30%, 50%, and 90% of repolarization, respectively. Sample numbers (n) indicate myocytes per mouse. DTX-K, dendrotoxin-K; KO, knockout; WT, wild-type.
*
P < 0.05 vs. control (Student’s paired t-test).