Fig. 5.

Arterial blood oxygen tension ($\text{P}{\text{a}}_{\text{O}}{}_{{}_2}$) and intrapulmonary shunt fraction (Qs/Qt) during LMBO in Ndufs4-deficient mice or Ndufs4^+/+ mice breathing 11% O₂ for 3 wk. In Ndufs4^−/− mice, $\text{P}{\text{a}}_{\text{O}}{}_{{}_2}$ was increased after treatment with 11% O₂ for 3 wk [n = 4 (male), n = 3 (female)] and was comparable to the level of $\text{P}{\text{a}}_{\text{O}}{}_{{}_2}$ in hypoxic Ndufs4^+/+ mice [n = 4 (male), n = 3 (female], Ndufs4^−/− vs. Ndufs4^+/+, P = not significant) (A). The calculated Qs/Qt fraction was decreased in Ndufs4^−/− mice [n = 4 (male), n = 3 (female)] and comparable to the shunt fraction in Ndufs4^+/+ mice [n = 4 (male), n = 3 (female)] after breathing 11% O₂ for 3 wk (Ndufs4^−/− vs. Ndufs4^+/+, P = not significant) (B). Group differences were compared by Student’s t-test. Data are expressed as means ± SE. LMBO, left mainstem bronchial occlusion.