Table 2.
QLTAF, µl⋅min−1⋅g−1 |
TSVRI, mmHg⋅min⋅g⋅ml−1 |
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Genotype | Treatment | n | Baseline | LMBO | Baseline | LMBO |
Ndufs4+/+ | Saline | 5 | 197 ± 13 | 197 ± 12 | 153 ± 11 | 161 ± 16 |
Ndufs4−/− | Saline | 5 | 233 ± 11 | 230 ± 8 | 154 ± 12 | 143 ± 7 |
Ndufs4+/+ | DMSO 100% (0.5 ml/kg) | 5 | 224 ± 7 | 228 ± 8 | 142 ± 10 | 154 ± 22 |
Ndufs4+/+ | Piericidin A (0.5 mg/kg) | 5 | 212 ± 10 | 202 ± 11 | 140 ± 16 | 151 ± 24 |
Ndufs4+/+ | After 3 wk at 0.11 | 5 | 187 ± 20 | 185 ± 22 | 167 ± 26 | 168 ± 17 |
Ndufs4−/− | After 3 wk at 0.11 | 5 | 218 ± 20 | 205 ± 18 | 147 ± 14 | 148 ± 8 |
Values are means ± SE. The effect of LMBO on each parameter was analyzed in each group by ANOVA with a post hoc correction for multiple comparisons. , fraction of inspired oxygen; LMBO, left mainstem bronchial occlusion; QLTAF, lower thoracic aortic blood flow; TSVRI, total systemic vascular resistance index.