Table 3.

Arterial blood gas analysis at the end of the hemodynamic studies in Ndufs4^−/− and Ndufs4^+/+ mice breathing at 100% O₂

Genotype	Treatment	n	pHa	$\text{P}{\text{a}}_{\text{O}}{}_{{}_2}$, mmHg	$\text{P}{\text{a}}_{\text{CO}}{}_{{}_2}$, mmHg	Hemoglobin, mg/dl	Base Excess, mmol/l
Ndufs4+/+	Saline	9	7.32 ± 0.02	335 ± 33	32 ± 3	10.8 ± 0.6	−8 ± 1.5
Ndufs4−/−	Saline	8	7.21 ± 0.03b	156 ± 20b	38 ± 3	11.6 ± 0.5	−11.3 ± 1.5
Ndufs4+/+	DMSO 100% (0.5 ml/kg)	8	7.32 ± 0.02	352 ± 38	34 ± 3	11.1 ± 0.3	−7.6 ± 1.6
Ndufs4+/+	Piericidin A (0.5 mg/kg)	7	7.28 ± 0.02	163 ± 32a,b	30 ± 1	10.6 ± 0.3	−11.6 ± 1.4
Ndufs4+/+	After 3 wk at ${\text{F}\mathrm{i}}_{{\text{O}}_{\text{2}}}$ 0.11	7	7.22 ± 0.02a	269 ± 36	30 ± 2	16 ± 0.8a	−14.5 ± 1.1a
Ndufs4−/−	After 3 wk at ${\text{F}\mathrm{i}}_{{\text{O}}_{\text{2}}}$ 0.11	7	7.14 ± 0.02a	336 ± 26	31 ± 1	15.1 ± 0.6a	−17.8 ± 1a

Values are means ± SE. Each parameter was analyzed in each group by ANOVA with a post hoc correction for multiple comparisons. ${\text{F}\mathrm{i}}_{{\text{O}}_{\text{2}}}$, fraction of inspired oxygen; $\text{P}{\text{a}}_{\text{CO}}{}_{{}_2}$, partial pressure of arterial carbon dioxide; $\text{P}{\text{a}}_{\text{O}}{}_{{}_2}$, partial pressure of arterial oxygen.

^aP < 0.05 vs. saline-treated Ndufs4^+/+ mice;

^bP < 0.05 vs. Ndufs4^+/+ mice in the same treatment group.