Fig. 2.

BPI fold-containing group A member 1-deficient (Bpifa1^−/−) mice have limited peribronchial and alveolar inflammation in response to lipopolysaccharide (LPS). A: tissue sections of paraffin-embedded lung tissue stained with hematoxylin-eosin from wild-type (WT; left) and Bpifa1^−/− mice (right) after treatment with LPS (LPS 8 h, LPS 24 h) or PBS (Control). Images obtained with optical microscope at ×20 magnification. B: assessment of peribronchial inflammation in WT (●) and Bpifa1^−/− mice (○) based on histology score. C: assessment of alveolar inflammation in WT and Bpifa1^−/− mice based on histology score. Each data point represents the mean inflammation score of 10 random fields scored within the same section. Black horizontal lines indicate mean values. Generalized linear mixed model: *P < 0.05. Data represent 2 experiments; n = 4–7 mice/group.