Fig. 8.

Reconstitution of C-X-C motif chemokine ligand 10 (Cxcl10) in BPI fold-containing group A member 1-deficient (Bpifa1^−/−) mice restores lung polymorphonuclear neutrophils (PMN). Wild-type (WT) and Bpifa1^−/− mice received intraperitoneal Cxcl10 before treatment with lipopolysaccharide (LPS). PMN bronchoalveolar lavage (BAL) counts were assessed at 24 h. A: %PMN isolated in BAL fluid (BALF). B: absolute PMN count in BALF after LPS. Bpifa1^+/+, ●; Bpifa1^−/−, ○; LPS, 5 μg/mouse, from Pseudomonas aeruginosa PAO1; Cxcl10, 0.6 μg/mouse; n = 5–8 mice/group. Mann-Whitney test: *P < 0.05. Horizontal lines indicate mean values. Data represent 2 experiments.