Table 2.
Immune response and host defense gene expression differences in Bpifa1−/− mice during acute inflammation
| Symbol | 0 h | 8 h | 24 h | P | |
|---|---|---|---|---|---|
| Chemokines and cytokines | |||||
| Chemokine (C-X-C motif) ligand 9 | Cxcl9 | −1.38 | −1.69 | −5.42 | 0.049 |
| Chemokine (C-X-C motif) ligand 10 | Cxcl10 | −1.06 | −1.99 | −4.56 | 0.036 |
| Chemokine (C-C motif) ligand 7 | Ccl7 | −1.12 | −1.79 | −3.83 | 0.021 |
| Chemokine (C-C motif) ligand 12 | Ccl12 | −1.12 | −1.47 | −3.80 | 0.018 |
| Interleukin 10 | Il10 | −1.01 | −2.70 | −2.79 | 0.018 |
| Chemokine (C-X-C motif) ligand 16 | Cxcl16 | −1.16 | −1.09 | −1.61 | 0.010 |
| Chemokine (C-X-C motif) ligand 15 | Cxcl15 | 1.22 | 1.22 | 1.50 | 0.029 |
| Cytokine receptors | |||||
| Chemokine (C-C motif) receptor 5 | Ccr5 | −1.31 | −1.59 | −2.24 | 0.036 |
| Interleukin 12 receptor, β1 | Il12rb1 | 1.07 | −1.77 | −2.09 | 0.036 |
| Interleukin 2 receptor, β-chain | Il2rb | −1.10 | −1.95 | −1.83 | 0.015 |
| Chemokine (C-X-C motif) receptor 3 | Cxcr3 | −1.16 | −1.56 | −1.66 | 0.015 |
| Interleukin 2 receptor, γ-chain | Il2rg | −1.10 | −1.44 | −1.60 | 0.015 |
| Chemokine (C-C motif) receptor 2 | Ccr2 | −1.50 | −1.84 | −1.19 | 0.049 |
| Involved in cell migration | |||||
| Integrin β2-like | Itgb2l | 1.23 | −3.33 | −2.65 | 0.028 |
| Cadherin, EGF LAG 7-pass G-type receptor 3 | Celsr3 | −1.13 | −1.73 | −1.52 | 0.046 |
| Selectin, lymphocyte | Sell | −1.15 | −1.64 | −1.44 | 0.049 |
| Selectin, platelet (p-selectin) ligand | Selplg | −1.05 | −1.51 | −1.43 | 0.019 |
| Cadherin 2 | Cdh2 | 1.12 | 1.49 | 1.53 | 0.039 |
| AMP and PRR signaling | |||||
| Granzyme B | Gzmb | −1.15 | −1.48 | −2.30 | 0.042 |
| Secretin | Sct | 1.18 | −1.43 | −2.24 | 0.016 |
| Toll-like receptor 3 | Tlr3 | −1.14 | −1.32 | −1.41 | 0.044 |
| Myeloid differentiation primary response gene 88 | Myd88 | −1.00 | −1.34 | −1.57 | 0.041 |
| Surfactant-associated protein B | Sftpb | 1.23 | 1.40 | 1.60 | 0.013 |
| Class I histocompatibility antigen superfamily | |||||
| Histocompatibility 2, T region locus 9 | H2-T9 | −1.08 | −1.42 | −1.86 | 0.010 |
| Histocompatibility 2, Q region locus 8 | H2-Q8 | −1.25 | −1.18 | −1.85 | 0.031 |
| Histocompatibility 2, T region locus 10 | H2-T10 | −1.09 | −1.20 | −1.79 | 0.020 |
| Histocompatibility 2, M region locus 11 | H2-M11 | −1.16 | −1.05 | −1.66 | 0.032 |
| Histocompatibility 2, T region locus 24 | H2-T24 | −1.10 | −1.28 | −1.60 | 0.031 |
| Histocompatibility 2, T region locus 23 | H2-T23 | −1.08 | −1.08 | −1.59 | 0.028 |
| Histocompatibility 2, M region locus 3 | H2-M3 | −1.11 | −1.27 | −1.53 | 0.007 |
Whole lung microarray results showing differential gene expression in untreated mice (0 h) and at 8 and 24 h (8 h, 24 h) after intranasal instillation of lipopolysaccharide (LPS). Data are represented as fold change (FC) from wild-type (WT) gene expression. Negative FC values denote lower gene expression relative to WT. Two-way ANOVA, false discovery rate < 0.05, at least one time point with FC >1.5. Bpifa1−/−, BPI fold-containing group A member 1 deficient; AMP, antimicrobial proteins, PRR, pathogen recognition receptors.