Fig. 2.

Effects of pharmacological signal transducer and activator of transcription 3 (STAT3) inhibition on lung (A) and liver (B) neutrophil infiltration during sepsis. Lung and liver myeloperoxidase (MPO) activity was determined in STAT3 inhibitor Stattic-treated nonobese and obese mice at 0 and 18 h after cecal ligation and puncture (CLP). Data represent means and SD and were analyzed by two-way ANOVA. *P ≤ 0.05 vs. 0-h CLP by diet; #P ≤ 0.05 vs. nonobese mice within treatment group; @P ≤ 0.05 vs. vehicle by diet. Open bars, nonobese; filled bars, obese (n = 7–10/group).