Fig. 6.

Effects of hepatic signal transducer and activator of transcription 3 (STAT3) inhibition on liver inflammation and injury. A: liver neutrophil infiltration as measured by myeloperoxidase (MPO) activity. B: plasma alanine amonotransfrase (ALT) levels. C: relative liver tumor necrosis factor-α (TNFα) gene expression as measured by RT-PCR for knockout (KO; STAT3^{f/f Alb-Cre+}) and littermate controls (STAT3^{f/wt Alb-Cre+}) at 0 and 18 h after cecal ligation and puncture (CLP). Vertical box represents 25th percentile (bottom line), median (middle line), and 75th percentile (top line) values; whiskers represent 10th and 90th percentiles. White box, control; gray box, KO. Data were analyzed by two-way ANOVA (n = 3–4/group). *P ≤ 0.05 vs. CLP 0 h within genotype; #P ≤ 0.05 vs. control at time after CLP.