Fig. 8.

Obesity enhances neutrophil infiltration to the liver in hepatic signal transducer and activator of transcription 3 knockout (H-STAT3 KO) mice during sepsis. Liver myeolperoxidase (MPO) activity was measured in normal (ND) and high-fat diet (HFD) control (STAT3^{f/wt Alb-Cre+}) and KO (STAT3^{f/f Alb-Cre+}) mice during sepsis. Vertical box represents 25th percentile (bottom line), median (middle line), and 75th percentile (top line) values; whiskers represent 10th and 90th percentiles. White box, ND; gray box, HFD. Data were analyzed by two-way ANOVA (n = 3–6/group). *P ≤ 0.05 vs. control within diet; #P ≤ 0.05 vs. ND within genotype.