Table 4.
Correlation analysis between glycerol Ra, endogenous glucose production, and glucose clearance rate (MCR) and biochemical parameters in individuals with T2D and obesity
| T2D (r, P) | Obese Control (r, P) | |
|---|---|---|
| Glucose MCR, 80 mIU/m2/min phase | ||
| FFA, 80 mIU/m2/min phase | −0.748, <0.001 | −0.612, 0.008 |
| Glycerol Ra, 10 mIU/m2/min phase | −0.363, 0.15 | −0.485, 0.04 |
| Waist-to-hip ratio | −0.608, 0.003 | −0.060, 0.79 |
| Liver fat, % | −0.487, 0.03 | −0.171, 0.51 |
| Visceral fat, % | −0.576, 0.02 | −0.429, 0.26 |
| Total Cholesterol | −0.459, 0.02 | −0.132, 0.61 |
| Serum fasting triglycerides | −0.627, 0.001 | −0.251, 0.32 |
| Alanine transferase | −0.426, 0.03 | −0.423, 0.06 |
| Highly selective C-reactive protein | −0.475, 0.02 | −0.245, 0.34 |
| White blood cell count | −0.481, 0.02 | −0.135, 0.59 |
| 3-day activity (METs) | 0.488, 0.02 | 0.357, 0.22 |
| Adiponectin | 0.574, 0.004 | 0.318, 0.21 |
| EGP, 16 mIU/m2/min phase | ||
| FFA concentration at 16 mIU/m2/min | 0.650, 0.02 | 0.790, <0.001 |
| Waist-to-hip ratio | 0.817, 0.004 | 0.298, 0.21 |
| IGF-1 | −0.620, 0.02 | 0.100, 0.76 |
| SHBG | −0.172, 0.56 | −0.595, 0.007 |
| Glycerol Rate of Appearance, 10 mIU/m2/min phase | ||
| Predicted EGP | 0.680, 0.003 | −0.029, 0.900 |
Correlates of insulin sensitivity per tissue type are shown for youth with and without T2D. Data are shown as [correlation coefficient (r), P value]. Bolded values indicate significance. EGP, endogenous glucose production; FFA, free fatty acid; MCR, metabolic clearance rate; METs, metabolic equivalents; Ra, rate of appearance; T2D, type 2 diabetes; SHBG, sex hormone binding globulin.