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. 2018 Nov 21;316(2):H298–H310. doi: 10.1152/ajpheart.00185.2018

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Fig. 6. — Phenylephrine (PE) cumulative dose-response curves for exposed femoral arteries in control (Ctrl) and transgenic (TG) mice in vivo; PE was applied by superfusion. A: PE dose versus artery diameter. Ctrl passive diameter (PD) = 404 ± 21 μm (n = 9); TG PD = 374 ± 5 μm (n = 11). B: PE-induced vasoconstriction (as %PD). C: PE-induced increase (Δ) in cytosolic Ca²⁺ concentration ([Ca²⁺]_CYT). Basal [Ca²⁺]_CYT was 221 ± 29 nM in Ctrl mouse arteries and 319 ± 36 nM in TG mouse arteries, but the normalized vasoconstriction curves (B) and Δ[Ca²⁺]_CYT curves (C) from Ctrl and TG mice were virtually superimposable (two-way ANOVA). Values are means ± SE.