Fig. 9.
Effects of superfusion of 100 nM angiotensin II (ANG II) with or without 100 nM losartan on the diameter (A), cytosolic Ca2+ concentration ([Ca2+]CYT; B), and tone [as %passive diameter (PD); C] of exposed femoral arteries in control (Ctrl) and transgenic (TG) mice in vivo. Losartan abolished nearly all of the ANG II-induced increases in [Ca2+]CYT and tone in both Ctrl and TG arteries. Values are means ± SE. Statistics were by two-way ANOVA. ***P < 0.001 vs. the respective basal Ctrl or TG mice; ##P < 0.01 vs. ANG II alone; ¶P < 0.05 vs. basal Ctrl mice. Numbers of mice are in parentheses.