Fig. 3.

Conduction velocity (CV) and action potential (AP) duration (APD) in the atria of FK506-binding protein 12 transgenic (αMyHC-FKBP12) mice. A: representative pictures of AP propagation in the atria by optical mapping. Scale bar = 2 mm. B: comparison of atrial CV between αMyHC-FKBP12 and nontransgenic (NTG) control mice. C: representative AP traces in single atrial myocytes. D–G: comparison of APD at 50%, 90%, and 50-70% repolarization (APD₅₀, APD₉₀, and APD_50–70, respectively) and the AP overshoot between atrial myocytes from αMyHC-FKBP12 (n = 19 cells/4 mice) and NTG control mice (n = 24 cells/4 mice). WT, wild type. Data are expressed as means ± SE. *P < 0.05 vs. NTG mice.