Table 1.
Properties of INa and ICa,L in atrial myocytes
| Nontransgenic | αMyHC-FKBP12 | |
|---|---|---|
| INa | ||
| Peak current density, pA/pF | 97.2 ± 5.8 (n = 20) | 38.7 ± 5.8* (n = 15) |
| Activation | ||
| V½, mV | −45.7 ± 1.0 (n = 12) | −43.1 ± 1.2 (n = 13) |
| k, mV | 6.54 ± 0.23 (n = 12) | 6.52 ± 0.38 (n = 13) |
| Inactivation | ||
| V½, mV | −92.1 ± 1.03 (n = 11) | −84.4 ± 4.4* (n = 13) |
| k, mV | 10.16 ± 0.85 (n = 11) | 9.27 ± 0.41 (n = 13) |
| ICa,L | ||
| Peak current density, pA/pF | 10.5 ± 0.66 (n = 12) | 18.4 ± 1.91* (n = 13) |
| Activation | ||
| V½, mV | −5.44 ± 0.39 (n = 12) | −7.56 ± 0.88 (n = 13) |
| k, mV | 6.78 ± 0.34 (n = 12) | 5.88 ± 0.19 (n = 13) |
| Inactivation | ||
| V½, mV | −27.1 ± 0.27 (n = 12) | −25.9 ± 1.02 (n = 12) |
| k, mV | 5.85 ± 0.23 (n = 12) | 4.93 ± 0.20 (n = 12) |
Values are means ± SE; n = number of cells from 4 mice. INa, Na+ current; ICa,L, L-type Ca2+ current; αMyHC-FKBP12, FK506-binding protein 12 transgenic mice; V½, midpoint voltage of maximal conductance/currents; k, slope factor.
*
P < 0.05 vs. nontransgenic mice.