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. 2018 Dec 5;121(2):609–619. doi: 10.1152/jn.00669.2018

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Fig. 2. — Synaptically released zinc is not required for mossy fiber calcium permeable-AMPA receptor (mossy fiber-CP-AMPAR) long-term depression (LTD). A, top: representative traces (inset) show individual excitatory postsynaptic currents (EPSCs) at time points before (1, black) and after (2, gray) high-frequency stimulation (HFS) of mossy fibers. Top left: HFS induced similar amounts of LTD in the presence of vehicle (63 ± 9%, n = 5, P = 0.02, paired t-test) or ZX1 (59 ± 6%, n = 9, P = 0.0002, paired t-test). Top right: values from individual cells are plotted. Comparison of vehicle- and ZX1-treated groups with Student’s t-test revealed no significant differences (P = 0.4). Bottom: repeated-measures two-way ANOVA revealed a P value of 0.227 for paired-pulse ratio (PPR) data in the two groups. B, top: representative traces (inset) of mossy fiber-CP-AMPAR EPSC were collected before (1, black) and after (2, gray) HFS of mossy fibers. Top left: HFS induced LTD of mossy fiber-CP-AMPAR EPSC in slices from both WT (77 ± 8%, n = 5, paired t-test, P = 0.02) and ZnT3^−/− mice (76 ± 4%, n = 10, paired t-test, P = 0.002). Top right: values from individual cells are plotted. Comparison of WT and ZnT3^−/− mice with Student’s t-test revealed no significant difference (P = 0.5). Bottom: repeated-measures two-way ANOVA revealed a P value of 0.564 for PPR data in the two groups.