Table 1.
Anatomic, hemodynamic, and echocardiographic measurements associated with failing hearts
| Sh-Veh | Sh-Cur | HF-Veh | HF-Cur | |
|---|---|---|---|---|
| n | 8 | 9 | 12 | 11 |
| Whole heart weight, g | 0.14 ± 0.01 | 0.14 ± 0.01 | 0.26 ± 0.04* | 0.28 ± 0.06‡ |
| Atria weight, mg | 15.0 ± 1.0 | 15.5 ± 0.7 | 43.1 ± 3.4* | 46.8 ± 2.6‡ |
| RVFW weight, mg | 26.95 ± 2.6 | 27.85 ± 2.2 | 64.8 ± 6.1* | 69.3 ± 7.3‡ |
| Septum weight, mg | 51.9 ± 2.0 | 50.7 ± 3.2 | 77.9 ± 9.5* | 86.3 ± 8.3‡ |
| LVFW weight, mg | 46.1 ± 3.7 | 45.96 ± 2.8 | 74.3 ± 8.6* | 74.66 ± 8.0‡ |
| Infarct size, % of LV | 0 | 0 | 79.4 ± 8.9† | 81.6 ± 6.4§ |
| Ejection fraction, % | 68.6 ± 8.4 | 67.3 ± 7.9 | 21.3 ± 2.1* | 19.5 ± 3.3‡ |
| Fractional shortening, % | 34.8 ± 5.5 | 36.1 ± 4.8 | 10.1 ± 2.1* | 11.3 ± 1.8‡ |
| LVEDP, mmHg | 1.3 ± 1.4 | 0.9 ± 2.1 | 29.8 ± 7.8† | 27.4 ± 6.3§ |
| dP/dtmax, mmHg/s | 12,138 ± 919 | 11,198 ± 1001 | 2,101 ± 315† | 2,198 ± 333§ |
| dP/dtmin, - mmHg/s | 12,952 ± 867 | 12,166 ± 981 | 2,540 ± 441† | 2,719 ± 462§ |
Values are means ± SE. RVFW, right ventricular free wall; LV, left ventricle; LVFW, LV free wall; LVEDP, LV end-diastolic pressure.
*
P < 0.01 and
†
P < 0.001 vs. Sh-Veh;
‡
P < 0.01 and
§
P < 0.001 vs. Sh-Cur.