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. 2018 Dec 20;126(2):431–443. doi: 10.1152/japplphysiol.00594.2018

Table 4.

Intensity thresholds most discriminative of BDNF responses exceeding MDC-UCL

Intensity Measure/BDNF MDC-UCL AUC [95% CI] Best Threshold Sensitivity, % Specificity, %
Blood lactate mean, mmol/l
    MDC80&85 0.88 [0.78, 0.98] 4.7 100 77
    MDC90 0.85 [0.74, 0.96] 4.7 100 75
    MDC95 0.88 [0.77, 0.99] 5.3 100 79
Blood lactate T5, mmol/l
    MDC80&85 0.87 [0.75, 0.99] 4.1 86 84
    MDC90 0.83 [0.70, 0.97] 4.1 83 82
    MDC95 0.89 [0.78, 1.00] 4.1 100 80
Blood lactate T10, mmol/l
    MDC80&85 0.90 [0.80, 1.00] 4.5 100 76
    MDC90 0.88 [0.76, 0.99] 4.5 100 74
    MDC95 0.94 [0.86, 1.00] 7.3 100 90
Mean V̇o2, %V̇o2peak
    MDC80&85 0.92 [0.84, 1.00] 67 100 82
    MDC90 0.91 [0.82, 1.00] 67 100 80
    MDC95 0.90 [0.80, 0.90] 72 100 81
Max V̇o2, %V̇o2peak
    MDC80&85 0.87 [0.72, 1.00] 116 71 97
    MDC90 0.85 [0.68, 1.00] 117 67 98
    MDC95 0.89 [0.71, 1.00] 120 75 98
Minutes 60–85% V̇o2peak
    MDC80&85 0.65 [0.46, 0.84] 6 100 44
    MDC90 0.66 [0.46, 0.87] 6 100 43
    MDC95 0.46 [0.20, 0.71] 7 75 55
Minutes ≥85% V̇o2peak
    MDC80&85 0.89 [0.78, 1.00] 4 86 85
    MDC90 0.88 [0.74, 1.00] 4 83 83
    MDC95 0.90 [0.80, 1.00] 4 100 81
Mean HR, %HRpeak
    MDC80&85 0.94 [0.87, 1.00] 84 100 89
    MDC90 0.95 [0.89, 1.00] 90 100 95
    MDC95 0.94 [0.87, 1.00] 90 100 90
Mean HR, %APmaxHRR
    MDC80&85 0.93 [0.85, 1.00] 74 100 84
    MDC90 0.91 [0.81, 1.00] 74 100 82
    MDC95 0.83 [0.71, 0.96] 74 100 78
Mean HR, %HRRpeak
    MDC80&85 0.94 [0.87, 1.00] 72 100 92
    MDC90 0.95 [0.88, 1.00] 76 100 92
    MDC95 0.95 [0.88, 1.00] 80 100 93
Mean HR, %APmaxHRR
    MDC80&85 0.92 [0.83, 1.00] 53 100 86
    MDC90 0.89 [0.79, 0.99] 53 100 84
    MDC95 0.83 [0.71, 0.96] 53 100 80
Minutes ≥85%HRR
    MDC80&85 0.94 [0.86, 1.00] 6 100 92
    MDC90 0.93 [0.85, 1.00] 6 100 89
    MDC95 0.93 [0.84, 1.00] 8 100 88

Receiver operating characteristic analysis of intensity variables with significant association to brain-derived neurotrophic factor (BDNF) response (see Table 2). The “best” threshold was the one that maximized (sensitivity + specificity). MDC-UCL, minimal detectable change upper confidence limits; AUC, area under the curve; V̇o2, oxygen consumption rate; HR, heart rate; HRR, heart rate reserve; peak, maximum value reached during symptom-limited, graded exercise test; APmax, age-predicted maximum.