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. 2018 Sep 27;126(2):341–353. doi: 10.1152/japplphysiol.00719.2018

Fig. 8.

Fig. 8.

Impaired mitochondrial oxidative phosphorylation response to exercise training with Mitofusin (Mfn) deletion. A–C: mRNA expression of nuclear-encoded electron transport chain (ETC) subunits NADH dehydrogenase 1 beta subunit 5 (ndufb5), succinate dehydrogenase complex iron sulfur subunit B (sdhb), cytochrome c, somatic (cycs), cytochrome-c oxidase subunit 5B (cox5b), citrate synthase (cs), and ATP synthase subunit O (atp5o) (A) and NADH dehydrogenase (complex I) (B) and cytochrome-c oxidase (complex IV) (C) activity in the subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondrial fractions from gastrocnemius muscle of adult-inducible skeletal muscle-specific Mfn1 and Mfn2 double knockout mice (iMS-MfnDKO; n = 5) and control littermates (n = 4). Data are presented as means ± SE. *P < 0.05 compared with sedentary control; #P < 0.05 compared with sedentary iMS-MfnDKO; %P < 0.05 compared with exercised control. P values were determined by 2-way ANOVA with pairwise comparisons (Tukey adjustment).