Table 1.
Control |
Exercise |
TAC |
|||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | 4 wk | P | 8 wk | P | Baseline | 4 wk | P | 8 wk | P | Baseline | 4 wk | P | 8 wk | P | |
HR, beats/min | 415 ± 41 | 410 ± 20 | NS | 404 ± 20 | NS | 425 ± 47 | 419 ± 35 | NS | 412 ± 35 | NS | 402 ± 39 | 411 ± 22 | NS | 421 ± 22 | NS |
PW, mm | 0.66 ± 0.03 | 0.7 ± 0.05 | NS | 0.70 ± 0.04 | NS | 0.66 ± 0.05 | 0.75 ± 0.03 | 0.002 | 0.81 ± 0.03 | 0.001 | 0.63 ± 0.05 | 0.93 ± 0.04 | 0.001 | 1.13 ± 0.06 | 0.001 |
LVEDD, mm | 4.3 ± 0.2 | 4.4 ± 0.3 | NS | 4.4 ± 0.2 | NS | 4.1 ± 0.1 | 4.7 ± 0.2 | 0.002 | 4.7 ± 0.4 | 0.002 | 4.5 ± 0.2 | 4.47 ± 0.3 | NS | 4.47 ± 0.3 | NS |
RWT, mm | 0.31 ± 0.02 | 0.31 ± 0.04 | NS | 0.31 ± 0.02 | NS | 0.32 ± 0.02 | 0.35 ± 0.03 | NS | 0.39 ± 0.03 | 0.01 | 0.31 ± 0.02 | 0.41 ± 0.03 | 0.002 | 0.5 ± 0.06 | 0.001 |
LV area, mm2 | 13.8 ± 0.6 | 13.9 ± 0.7 | NS | 13.9 ± 0.7 | NS | 13.5 ± 0.7 | 16.1 ± 0.6 | 0.002 | 19.7 ± 0.9 | 0.001 | 14.4 ± 0.4 | 13.9 ± 0.6 | NS | 13.9 ± 0.6 | NS |
EF, % | 60.2 ± 0.9 | 60.3 ± 0.4 | NS | 59.1 ± 0.8 | NS | 58.0 ± 0.2 | 59.3 ± 0.3 | NS | 60.5 ± 0.5 | NS | 59.4 ± 0.6 | 53.8 ± 0.5 | NS | 44.6 ± 0.9 | 0.001 |
E/A | 1.89 ± 0.8 | 1.91 ± 0.6 | NS | 1.92 ± 0.9 | NS | 1.91 ± 0.6 | 2.2 ± 0.7 | NS | 2 ± 0.9 | NS | 1.9 ± 0.7 | 2.1 ± 0.5 | NS | 2.9 ± 0.8 | 0.001 |
E′/A′ | 1.45 ± 0.2 | 1.64 ± 0.3 | NS | 1.61 ± 0.3 | NS | 1.46 ± 0.3 | 1.65 ± 0.4 | NS | 1.55 ± 0.3 | NS | 1.6 ± 0.6 | 1.57 ± 0.2 | NS | 1.5 ± 0.5 | NS |
E/E′ | 32.3 ± 5.2 | 32.5 ± 6.1 | NS | 32.8 ± 3.8 | NS | 31.2 ± 4.9 | 30.4 ± 5.7 | NS | 28.2 ± 5.0 | NS | 32.6 ± 3.7 | 33.5 ± 6.3 | NS | 37 ± 6.2 | 0.002 |
s′, mm/s | 20.1 ± 4.2 | 20.7 ± 3.1 | NS | 20.9 ± 5.1 | NS | 19.6 ± 4.1 | 27.8 ± 5.4 | 0.046 | 29.2 ± 2.3 | 0.001 | 21 ± 3.6 | 18.7 ± 4.6 | NS | 17 ± 4.2 | 0.04 |
Values are means ± SE. HR, heart rate; PW, posterior wall; LVEDD, left ventricular end-diastolic dimension; RWT, relative wall thickness; LV, left ventricle; EF, ejection fraction; NS, nonsignificant.