Table 6.
Responsiveness: mean change of QOL in changed health status in anchor; significant changes of QOL confirm responsiveness
| Improvement in the specific anchor | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FVC | DLCO | 6MWD | SF-36 item | TDI | NYHA | |||||||
| na | 9–11 | 10–11 | 14–17 | 10–15 | 15–16 | 18–19 | ||||||
| mean | sd | mean | sd | mean | sd | mean | sd | mean | sd | mean | sd | |
| PSC | 6.2* | 6.5 | −3.9 | 9.6 | 3.0 | 10.5 | 4.0 | 10.1 | 4.3* | 11.1 | 1.8 | 9.4 |
| MSC | −3.6 | 13.1 | −1.8 | 10.5 | −1.1 | 10.2 | −0.7 | 9.0 | −0.7 | 8.3 | −1.4 | 7.3 |
| PFI | 15.3 | 24.0 | −3.9 | 19.9 | 1.6 | 19.7 | 5.4* | 11.7 | 5.5 | 18.9 | −3.2 | 24.1 |
| ROLEM | −16.7 | 72.4 | 0.0 | 64.8 | −8.9 | 47.9 | 0.0 | 62.9 | −6.3 | 42.5 | −20.4* | 36.4 |
| ROLPH | 17.5 | 39.2 | −25.0 | 45.6 | 11.7 | 28.1 | 30.0 | 55.0 | 20.3 | 44.0 | 2.8 | 34.2 |
| GHP | 7.1 | 20.8 | −11.9* | 14.6 | 2.3 | 14.5 | 4.1 | 24.2 | 5.0 | 22.8 | 2.6 | 19.4 |
| MHI | 2.0 | 19.0 | −4.2 | 10.2 | 3.2 | 11.7 | −1.0 | 9.6 | 1.9 | 16.7 | 1.7 | 11.7 |
| VITAL | 4.5 | 12.8 | −2.3 | 14.0 | 4.4 | 13.4 | 4.0 | 16.5 | 7.4 | 14.8 | 1.1 | 14.1 |
| SOCIAL | 1.1 | 30.8 | −10.2* | 9.4 | 0.0 | 15.3 | 1.8 | 18.9 | 3.1 | 23.0 | 6.6 | 21.0 |
| PAIN | 0.2 | 31.9 | 4.9 | 23.9 | 11.5 | 28.8 | 1.3 | 23.8 | −0.3 | 36.1 | 6.9 | 29.6 |
| deterioration in the specific anchor | ||||||||||||
| FVC | DLCO | 6MWD | SF-36 item | TDI | NYHA | |||||||
| na | 30–36 | 22–28 | 29–36 | 37–45 | 55–73 | 29–40 | ||||||
| mean | sd | mean | sd | mean | sd | mean | sd | mean | sd | mean | sd | |
| PSC | −2.6 | 10.3 | −5.0 | 10.4 | −2.8* | 8.5 | −3.0* | 9.5 | −2.4 | 7.8 | −1.1 | 9.0 |
| MSC | −2.9 | 13.0 | −2.8 | 10.0 | 0.1 | 9.6 | −3.0* | 9.5 | −0.7 | 8.3 | −1.0 | 11.0 |
| PFI | −12.9* | 23.8 | −14.1* | 25.0 | −9.3* | 21.4 | −10.2* | 22.3 | −3.9 | 21.3 | − 2.7 | 25.2 |
| ROLEM | −7.3 | 62.1 | −15.9 | 49.1 | −3.1 | 44.3 | −4.4 | 48.5 | −1.7 | 37.9 | 2.2 | 57.7 |
| ROLPH | −2.3 | 51.7 | −15.0 | 36.8 | −14.5* | 33.0 | −10.1 | 35.8 | −9.0* | 35.7 | −4.9 | 39.6 |
| GHP | −7.3* | 17.1 | −6.9 | 16.8 | −2.3 | 17.4 | −5.0 | 15.0 | −4.8* | 13.8 | −6.7 | 17.1 |
| MHI | −8.1 | 17.2 | −4.4 | 17.3 | −2.1 | 14.5 | −5.8 | 17.3 | −4.1* | 13.5 | −3.3 | 17.7 |
| VITAL | −8.2* | 18.8 | −3.7 | 22.0 | −3.0 | 15.7 | −6.8* | 15.0 | −4.7* | 15.8 | −0.4 | 19.3 |
| SOCIAL | −10.8* | 29.6 | −12.9* | 25.6 | −7.3 | 30.5 | − 13.3* | 24.8 | −1.5 | 23.2 | − 14.1* | 32.2 |
| PAIN | −3.1 | 32.6 | −10.0 | 35.1 | 4.6 | 27.4 | −3.3 | 37.9 | −2.7 | 27.3 | −8.1 | 31.0 |
a sample size varying depending on temporal relation of anchors and filled in SF-36, number of missing items within SF-36 and the possibility to calculate dimensions and summary scores
SD standard deviation
*p < 0.05
**p < 0.001
Abbreviations: PCS Physical component score, MCS Mental component score, GHP General health perceptions, PFI Physical functioning, ROLPH physical role functioning, ROLEM emotional role functioning, SOCIAL Social role functioning, MHI Mental health, PAIN bodily pain, VITAL vitality, sd standard deviation, FVC Forced vital capacity, DLCO Diffusing capacity of the lungs for carbon monoxide, 6MWD 6 min walking distance, SF-36 item indicating health status of the last year, TDI Transitional Dyspnoea Index, NYHA New York Heart Association