Table 1.
Functional significance of the 24 metabolic genes predicted by the model to impact acetylation
| Gene | Gene description | 1. Acetylated? | 2. Interacts with acetylase? | 3. Interacts with deacetylase? | 4. Sirtuin target? |
|---|---|---|---|---|---|
| AASS | Aminoadipate-semialdehyde synthase | X | |||
| ACLY | ATP citrate lyase | X | X | X | |
| ACO2 | Aconitase 2, mitochondrial | X | X | X | |
| ALDH1L1 | Aldehyde dehydrogenase 1 family, member L1 | X | |||
| CS | Citrate synthase | X | X | X | |
| FAH | Fumarylacetoacetate hydrolase (fumarylacetoacetase) | X | |||
| FH | Fumarate hydratase | X | X | X | |
| GOT1 | Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | X | |||
| GSTZ1 | Glutathione transferase zeta 1 | X | |||
| HGD | Homogentisate 1,2-dioxygenase | X | |||
| HPD | 4-Hydroxyphenylpyruvate dioxygenase | ||||
| IDH2 | Isocitrate dehydrogenase 2 (NADP+), mitochondrial | X | X | X | |
| PC | Pyruvate carboxylase | X | X | ||
| OAT | Ornithine aminotransferase | X | X | X | |
| RBKS | Ribokinase | ||||
| RPE | Ribulose-5-phosphate-3-epimerase | ||||
| SDHA | Succinate dehydrogenase complex, subunit A, flavoprotein | X | X | X | X |
| SDHB | Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | X | X | X | |
| SDHC | Succinate dehydrogenase complex, subunit C | X | |||
| SDHD | Succinate dehydrogenase complex, subunit D | X | |||
| SHMT1 | Serine hydroxymethyltransferase 1 (soluble) | X | X | ||
| SLC25A1 | Solute carrier family 25 (mitochondrial carrier; citrate transporter) | X | X | X | |
| SUOX | Sulfite oxidase | X | |||
| TALDO1 | Transaldolase 1 | X | X |
Column 1 shows acetylation status based on protein acetylation database. Column 2 shows proteins that are found to physically interact with an acetylase. Column 3 shows proteins that are found to physically interact with a deacetylase enzyme. Column 4 shows predicted targets of sirtuins, a major class of deacetylases (X mark implies true)