Fig. 1.

Transcriptomic landscape of epithelial ovarian cancer. a Volcano plot showing significantly differentially expressed coding gene mRNAs in six EOC tissues versus three matched normal ovary tissues. 2552 significantly differentially mRNAs were indicated in the two upper lateral quadrants with absolute fold change ≥2 and p value < 0.01. b Heatmap of the 2552 significantly differentially expressed mRNAs showing clear hierarchical clustering using Pearson correlation and average linkage. c KEGG pathway enrichment analysis showing the 2552-gene signature to be significantly enriched in important cellular pathways. d Volcano plot showing significantly differentially expressed long non-coding RNAs in six EOC tissues versus three matched normal ovary tissues. 288 significantly differentially lncRNAs were indicated in the two upper lateral quadrants with absolute fold change ≥2 and p value < 0.01. e Heatmap of the 288 significantly differentially expressed lncRNAs showing clear hierarchical clustering using Pearson correlation and average linkage. f Ten out of the 288 significantly differentially expressed lncRNAs were randomly selected and validated in an independent cohort of 50 patient samples. * indicated statistically significantly differentially expressed lncRNAs in the validation cohort. * denotes p < 0.05, **denotes p < 0.01, ***denotes p < 0.001